李文静

李文静  /  

  • 职  称: 副研究员
  • 邮  编: 100190
  • 电子邮件: wenjing.li@ia.ac.cn
  • 部门/实验室: 多模态人工智能系统全国重点实验室
  • 通讯地址: 北京市海淀区中关村东路95号中科院自动化研究所自动化大厦

个人简历

教育经历:
(1) 2008-10 至 2012-10, 名古屋大学, 生命理学, 博士
(2) 2005-09 至 2008-06, 山东大学, 分子生物学与微生物学, 硕士
(3) 2001-09 至 2005-06, 山东大学, 生命科学, 学士
博士后工作经历:
(1) 2013-12 至 2017-12, 清华大学
科研与学术工作经历(博士后工作经历除外):
(1) 2013-01 至 今, 中国科学院生物物理研究所, 无, 助理研究员
(2) 2019-04 至 今, 中国科学院自动化研究所, 多模态人工智能系统全国重点实验室, 副研究员

研究方向

细胞生物学,人工智能

承担科研项目情况

(1) 国家自然科学基金委员会, 重大研究计划, 92354307, 全细胞尺度细胞器互作网络时空图谱绘制与分
析, 2024-01-01 至 2025-12-31, 240万元, 在研, 参与
(2) 国家自然科学基金委员会, 重大研究计划, 91954201, 全细胞尺度溶酶体空间分布与互作调控的计算
分析与建模, 2020-01-01 至 2023-12-31, 254万元, 资助期满, 参与
(3) 国家自然科学基金委员会, 面上项目, 31971289, 基于深度学习的生物荧光显微图像分割关键技术研
究与应用, 2020-01-01 至 2023-12-31, 60万元, 资助期满, 参与                                           (4) 北京市自然科学基金, 面上, 5202022, 系统性定量分析用于细胞器互作在内质网应激下动态响应与调控机制的研究, 2020-2023 至 今, 20万元, 结题, 主持

代表论著

[1] R. Xu, T. Li, J. Luo, X. Zhang, T. Wang, Y. Wang, Y. Ma, B. Yang, J. Jia, A.A. Dmytriw, W. Li, L. Jiao, PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells, CNS Neurosci Ther 30(2) (2024) e14640.
[2] J. Luo, X. Zhang, W. Li, T. Wang, S. Cui, T. Li, Y. Wang, W. Xu, Y. Ma, B. Yang, Y. Luo, G. Yang, R. Xu, L. Jiao, eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque, Heliyon 10(5) (2024) e26904.
[3] Z.W. Yating, Li and Ge, Yang, SCTS: Instance Segmentation of Single Cells Using a Transformer-Based Semantic-Aware Model and Space-Filling Augmentation, 2023 IEEE/CVF Winter Conference on Applications of Computer Vision (WACV) 2023 (2023) 5933-5942.
[4] L. Wenjing, Q. Mengxuan, Z. Yudong, G. Yuanhao, Y. Yutong, H. Junjie, Y. Ge, ER mediates spatial regulation of lysosome-endosome interactions via motion switch at junction sites, bioRxiv  (2023) 2023.09.23.558934.
[5] T. Wang, Y. Wang, X. Zhang, W. Xu, K. Jin, Y. Pang, Y. Wu, J. Luo, R. Xu, L. Jiao, W. Li, Mechanism of Oxidized Phospholipid-related Inflammatory Response in Vascular Ageing, Ageing Research Reviews  (2023) 101888.
[6] W. Li, Y. Pang, K. Jin, Y. Wang, Y. Wu, J. Luo, W. Xu, X. Zhang, R. Xu, T. Wang, L. Jiao, Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging, WIREs Mechanisms of Disease n/a(n/a) (2023) e1612.
[7] T. Wang, J. Zhou, X. Zhang, Y. Wu, K. Jin, Y. Wang, R. Xu, G. Yang, W. Li, L. Jiao, X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis, Aging and disease  (2022) 0-.
[8] W. Li, K. Jin, J. Luo, W. Xu, Y. Wu, J. Zhou, Y. Wang, R. Xu, L. Jiao, T. Wang, G. Yang, NF-κB and its crosstalk with endoplasmic reticulum stress in atherosclerosis, Frontiers in Cardiovascular Medicine 9 (2022).
[9] Y. Guo, J. Huang, Y. Zhou, Y. Luo, W. Li, G. Yang, Segmentation of Intracellular Structures in Fluorescence Microscopy Images by Fusing Low-Level Features, PRCV 2021, Springer International Publishing, Cham, 2021, pp. 386-397.
[10] L. Yaoru, G. Yuanhao, L. Wenjing, L. Guole, Y. Ge, Fluorescence Microscopy Image Datasets for Deep Learning Segmentation of Intracellular Orgenelle Networks, 2020.
[11] W. Li, S. Zhang, G. Yang, Dynamic organization of intracellular organelle networks, Wiley Interdiscip Rev Syst Biol Med  (2020) e1505.
[12] D. Wu, Y. Chai, Z. Zhu, W. Li, G. Ou, W. Li, CED-10-WASP-Arp2/3 signaling axis regulates apoptotic cell corpse engulfment in C. elegans, Developmental biology 428(1) (2017) 215-223.
[13] W. Li, P. Yi, Z. Zhu, X. Zhang, W. Li, G. Ou, Centriole translocation and degeneration during ciliogenesis in Caenorhabditis elegans neurons, The EMBO journal 36(17) (2017) 2553-2566.
[14] Z. Zhu, Y. Chai, Y. Jiang, W. Li, H. Hu, W. Li, J.W. Wu, Z.X. Wang, S. Huang, G. Ou, Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration, Developmental cell 39(2) (2016) 224-238.
[15] W. Li, P. Yi, G. Ou, Somatic CRISPR–Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia, The Journal of cell biology 208(6) (2015) 683-692.
[16] A.A. Głuszek, C.F. Cullen, W. Li, R.A. Battaglia, S.J. Radford, M.F. Costa, K.S. McKim, G. Goshima, H. Ohkura, The microtubule catastrophe promoter Sentin delays stable kinetochore–microtubule attachment in oocytes, The Journal of cell biology 211(6) (2015) 1113-1120.
[17] W. Li, T. Moriwaki, T. Tani, T. Watanabe, K. Kaibuchi, G. Goshima, Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin, The Journal of cell biology 199(5) (2012) 849-862.
[18] W. Li, T. Miki, T. Watanabe, M. Kakeno, I. Sugiyama, K. Kaibuchi, G. Goshima, EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells, The Journal of cell biology 193(6) (2011) 973-983.
[19] J. Sheng, K. An, C. Deng, W. Li, X. Bao, D. Qiu, Cloning a cuticle-degrading serine protease gene with biologic control function from Beauveria brongniartii and its expression in Escherichia coli, Current microbiology 53(2) (2006) 124-128.

获奖及荣誉

加藤纪念国际交流助成基金2010
名古屋大学青年研究者基金,2011

专利成果

李文静; 郭远昊; 杨戈 ; 用于确定内质网表型的方法及产品和用于药物筛选的方法, 2021-2-3, 中
国, 202110150528.7

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