影像大数据智能分析

医学影像处理与分析

医学分子影像

1. 科技部国家重点研发计划（共性技术）《新型多模态影像融合技术研发及其疾病早期筛查和精准诊疗应用-多模态成像及多模态图像融合新方法新技术》，360万，2024-2028年度，项目号2023YFC3402804,课题负责人

2. 国家自然基金委面上项目《基于新型磁纳米粒子成像在体定量可视化乳腺肿瘤乏氧关键分子表达及指导治疗研究》，52万，2023-2026年度，项目编号82272111， 项目负责人

3. 国家自然科学基金重大研究计划集成项目《恶性肿瘤免疫表型转化关键调控分子的可视化诊疗策略》，共350万，到位经费87.5万，项目编号92159303，2022.01-2025.12，课题负责人

4. 北京市自然科学基金面上项目《乳腺肿瘤及微小转移的新型光学和MPI/MRI多模态分子影像在体精准检测研究》，项目编号7212207，20万， 2021-2023年度，项目负责人

5. 国家自然基金委面上项目《针对早期乳腺肿瘤和微小转移的新型磁纳米粒子成像研究》，项目编号81871514，57万，2019-2022年度，项目负责人

6. 国家自然基金委面上项目《针对肿瘤相关巨噬细胞在乳腺肿瘤发展中分布和作用的分子影像学研究》，项目编号81470083，73万，2015-2018年度， 项目负责人

1. Zeyu Zhang#, Yang Du#, Xiaojing Shi#, Kun Wang, Qiaojun Qu, Qian Liang, Xiaopeng Ma, Kunshan He, Chongwei Chi, Jianqiang Tang, Bo Liu, Jiafu Ji*, Jun Wang*, Jiahong Dong*, Zhenhua Hu* & Jie Tian* (2024). NIR-II light in clinical oncology: opportunities and challenges. Nat Rev Clin Oncol. 2024, Accepted (2022 SCI: 78.8) (Review)

2. Zhou M#, Xiang S#, Zhao Y#, Tang Y, Yang J, Yin X, Tian J*, Hu S*, Du Y* (2023). [68Ga]Ga-AUNP-12 PET Imaging to Assess the PD-L1 Status in Preclinical and First-in-human Study. Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):369-379. (2022 SCI:9.1) 

3. Zhang W#, Liang X#, Zhang X#, Tong W, Shi G, Guo H, Jin Z*, Tian J*, Du Y*, Xue H* (2024), Magnetic-optical Dual-modality Imaging Monitoring Chemotherapy Efficacy of Pancreatic Ductal Adenocarcinoma with a Low-dose Fibronectin-targeting Gd-based Contrast Agent. Eur J Nucl Med Mol Imaging. https://doi.org/10.1007/s00259-024-06617-w. (2022 SCI: 9.1)

4. Guangyuan Shi, Xiaoli Liu*, Yang Du*, Jie Tian* (2024). RGD Targeted Magnetic Ferrite Nanoparticles Enhance Antitumor Immunotherapeutic Efficacy by Activating STING Signaling Pathway. iScience. DOI: https://doi.org/10.1016/j.isci.2024.109062. (2022 SCI: 5.8)

5. Kun Wang#, Yang Du#, Zeyu Zhang#, Kunshan He, Zhongquan Cheng, Lin Yin, Di Dong, Changjian Li, Wei Li, Zhenhua Hu, Chong Zhang, Hui Hui, Jie Tian* (2023). Fluorescence image-guided tumour surgery. Nature Reviews Bioengineering 1,161-179(2023). (Review) (Cover article)

6. Zhang J#, Li W#, Qi Y#, Wang G, Li L, Jin Z*, Tian J*, Du Y* (2023). PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy Against Cancer with Enhanced Safety. Angew Chem Int Ed Engl. 2023 Jan 26;62(5):e202214750. (2022 SCI: 16.6) (Cover article)

7. Peng Z#, Lu C#, Shi G#, Yin L, Liang X, Song G*, Tian J*, Du Y* (2023). Sensitive and quantitative in vivo analysis of PD-L1 using magnetic particle imaging and imaging-guided immunotherapy. Eur J Nucl Med Mol Imaging. 2023 Apr;50(5):1291-1305. (2022 SCI:9.1) 

8. Wang G#, Li W, Shi G, Tian Y, Kong L, Ding N, Lei J, Jin Z*, Tian J*, Du Y* (2022). Sensitive and specific detection of breast cancer lymph node metastasis through dual-modality magnetic particle imaging and fluorescence molecular imaging: a preclinical evaluation. Eur J Nucl Med Mol Imaging. 2022 Jul;49(8):2723-2734. (2022 SCI: 9.1) 

9. Wang L#, Huang Y, Zhao Y, Tian J*, Zhang L*, Du Y* (2023). Improved Quantitative Analysis Method for Magnetic Particle Imaging Based on Deblurring and Region Scalable Fitting. Mol Imaging Biol https://doi.org/10.1007/s11307-023-01812-x. (2022 SCI: 3.1)

10. Peng Z#, Yin L#, Sun Z, Liang Q, Ma X, An Y*, Tian J*, Du Y*（2023）. DERnet: A Deep Neural Network for End-to-end Reconstruction in Magnetic Particle Imaging. Phys Med Biol 2023 Dec 22;69(1). (2022 SCI:3.5)

11. Shan S, Zhang C, Yin L, Yang X, Yu D, Qi Y, Li M, Wildgruber M, Du Y*, Tian J*, Ma X* (2024). Combination of Time Domain-System Matrix and X-space Methods to Reconstruct Magnetic Particle Images with Isotropic Resolution. Phys Med Biol 2024 Jan 2. doi: 10.1088/1361-6560/ad19f0. (2022 SCI: 3.5) 

12. Yin L, Guo H, Zhang P, Li Y, Hui H, Du Y*, Tian J* (2023). System matrix recovery based on deep image prior in magnetic particle imaging. Phys Med Biol 2023 Jan 20;68(3). (2022 SCI:3.5) 

13. Li G, Liu Y, Qian Z, Xiong F, Lei S, Feng Y, Li J, Du Y*, Tian J*, An Y* (2023). Fast system matrix generation based on single angle calibration in open-sided field free line magnetic particle imaging. IEEE Trans Biomed Eng. 2023 Nov 8:PP. doi: 10.1109/TBME.2023.3331028. (2022 SCI:4.6) 

14. Lin Y#, Y Du*, Hui Hui*, Jie Tian*. A Streamlined 3D Magnetic Particle Imaging System with A Two-stage Excitation Feed-through Compensation Strategy. IEEE Transactions on Instrumentation & Measurement (Accepted) (2022 SCI:5.6) 

15. Yu An#, Hanfang Wang#, Jiaqian Li, Guanghui Li, Xiaopeng Ma*, Yang Du*, Jie Tian* (2023). Reconstruction based on adaptive group least angle regression for fluorescence molecular tomography. Biomed Opt Express. 2023 May; 14(5);2225-2239. (2022 SCI: 3.4)

16. Yan D#, An Y#,*, Li G, Li J, Du Y*, Tian J* (2023). High-Resolution Reconstruction of FMT Based on Elastic Net Optimized by Relaxed ADMM. IEEE Trans Biomed Eng. 2023 Jan;70(1):296-306. (2022 SCI: 4.6). 

17. Cheng Z#, Shang J#, Wang H, Yu L, Yuan Z*, Zhang Y*, Du Y*, Tian J* (2023). Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives. J Control Release. 2023 Aug; 362:97-120. (2022 SCI: 10.8). (Review)

18. Cheng Z#, Ma J#, Yin L, Yu L, Yuan Z*, Zhang B*, Tian J*, Du Y* (2023). Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications. Eur J Nucl Med Mol Imaging 2023 Mar;50(4):1111-1133. (2022 SCI: 9.1) (Review)

19. Cheng Z#, Jin Y#, Li J, Shi G, Yu L, Shao B, Tian J*, Du Y*, Yuan Z* (2023). Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer. J Nanobiotechnology 2023 Mar 28;21(1):112. (2022 SCI:10.2)

20. Yin L#, Li W#, Du Y, Wang K, Liu Z, Hui H, Tian J* (2022). Recent developments of the reconstruction in magnetic particle imaging. Vis Comput Ind Biomed Art. 2022 Oct 1;5(1):24. (2022 SCI:2.8) 

21. Du Y#, Liu Y#, Wang D#, Bai H, Wang Z, He X, Zhang P, Tian J*, Wang J* (2022). Peptidic microarchitecture-trapped tumor vaccine combined with immune checkpoint inhibitor or PI3Kγ inhibitor can enhance immunogenicity and eradicate tumors. J Immunother Cancer 2022 Feb;10(2):e003564. (2022 SCI:10.9）

22. Zhang P#, Du Y#, Bai H, Wang Z, Duan J, Wang X, Zhong J, Wan R, Xu J, He X, Wang D, Fei K, Yu R, Tian J*, Wang J* (2022). Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors. BMC Med 2022 Nov 9;20(1):435. (2022 SCI: 9.3) 

23. Zhang W#, Liang X#, Zhu L, Zhang X, Jin Z*, Du Y*, Tian J*, Xue H* (2022), Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice. EBioMedicine. 2022 Jun;80:104040. (2022 SCI: 11.1）

24. Tian Y#, Tang C#, Shi G, Wang G, Du Y*, Tian J*, Zhang H* (2022). Novel fluorescent GLUT1 inhibitor for precision detection and fluorescence image-guided surgery in oral squamous cell carcinoma. Int J Cancer. Aug 1;151(3):450-462. (2022 SCI:6.4）

25. An Y*,#, Bian C#, Yan DX#, Wang H, Wang Y, Du Y*, Tian J* (2022). A fast and automated FMT/XCT reconstruction strategy based on standardized imaging space. IEEE Trans Med Imaging 2022 Mar;41(3):657-666. (2022 SCI: 10.6) 

26. Yang Du#,*, Pei Zhang#, Wei Liu, Jie Tian* (2022). Optical imaging of epigenetic modifications in cancer: A systematic review. Phenomics 2, 88–101 (2022) (Review)

27. Cheng Z#, Du Y#,*, Yu L, Yuan Z*, Tian J*. Application of Noninvasive Imaging to Combined Immune Checkpoint Inhibitors for Breast Cancer: Facts and Future. Mol Imaging Biol. 2022 Apr;24(2):264-279. (2022 SCI: 3.1) (Review)

28. Wang H#, Bian C#, Kong L, An Y*, Du Y*, Tian J* (2021). A Novel Adaptive Parameter Search Elastic Net Method for Fluorescent Molecular Tomography. IEEE Trans Med Imaging. 2021 May;40(5):1484-1498. (2022 SCI: 10.6) 

29. Jiang Z#, Han X#, Du Y#, Li Y, Li Y, Li J*, Tian J*, Wu A* (2021). Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging. Nano Lett. 2021 Apr 14;21(7):2730-2737.  (2022 SCI: 10.8) 

30. Bian C#, Wang Y#, Lu ZH, An Y, Wang HF, Kong LX, Du Y*, Tian J* (2021). ImmunoAIzer: A Deep learning-based computational frame-work to characterize cell distribution and gene mutation in tumor microenvironment. Cancers (Basel). 2021 Apr 1;13(7):1659.（2022 SCI: 5.2）

31. Zhang L#, Ding Y#, Chen X#, Xiang D, Shi F, Chen Y, Yan S, Zhang X, Tian J, Sivaprasad S, Du Y*, Yang Z*, Tian B* (2021). In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy. Biomed. Opt. Express. 2021 Oct 29;12(11):7185-7198. (2022 SCI: 3.4)

32. He X#, Du Y#, Wang Z, Wang X, Duan J, Wan R, Xu J, Zhang P, Wang D, Tian Y, Han J, Fei K, Bai H*, Tian J*, Wang J* (2020). Upfront dose-reduced chemotherapy synergizes with immunotherapy to optimize chemoimmunotherapy in squamous cell lung carcinoma. J Immunother Cancer. 2020 Oct;8(2):e000807. (2022 SCI: 10.9）

33. Zhou T#, Liang X#, Wang P, Hu Y, Qi Y, Jin Y, Du Y*, Fang C*, Tian J* (2020). A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that Inhibits Metastasis and Recurrence Combined with Immunotherapy. ACS Nano. 2020 Oct 27;14(10):12679-12696. (2022 SCI: 17.1)

34. Sun T#, Zhang W, Li Y, Jin Z, Du Y*, Tian J*, Xue H* (2020). Combination immunotherapy with cytotoxic T lymphocyte-associated antigen-4 and programmed death protein-1 inhibitors prevents postoperative breast tumor recurrence and metastasis. Mol Cancer Ther. 2020 Mar;19(3):802-811. (2022 SCI:5.7) 

35. Kong L#, An Y#, Liang Q, Yin L, Du Y*, Tian J* (2020). Reconstruction for Fluorescence Molecular Tomography via Adaptive Group Orthogonal Matching Pursuit. IEEE Trans Biomed Eng. 2020 Sep;67(9):2518-2529. (2022 SCI: 4.6). 

36. Liang Q#, Kong L#, Zhu X*, Du Y*, Tian J* (2019). Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma. Mol Imaging Biol. 2020 Dec;22(6):1455-1468. (2022 SCI: 3.1) 

37. Tang C#, Du Y#, Liang Q, Cheng Z*, Tian J* (2020). Development of a Novel Histone Deacetylase-Targeted Near-Infrared Probe for Hepatocellular Carcinoma Imaging and Fluorescence image-Guided Surgery. Mol Imaging Biol. 2020 Jun;22(3):476-485. (2022 SCI: 3.1) 

38. Du Y#, Liu X#, Liang Q#, Liang XJ*, Tian J*(2019). Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy. Nano Lett. 2019 Jun 12;19(6):3618-3626. (2022 SCI: 10.8). 

39. Liu X#, Zheng J#, Sun W#, Zhao X, Li Y, Gong N, Wang Y, Ma X, Zhang T, Zhao LY, Hou Y, Wu Z, Du Y*, Fan H*, Tian J*, Liang XJ* (2019). Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis. ACS Nano. 2019 Aug 27;13(8):8811-8825. (2022 SCI: 17.1) 

40.  Du Y#, Qi Y#, Jin Z*, Tian J* (2019). Noninvasive Imaging in Cancer Immunotherapy: The Way to Precision Medicine. Cancer Lett. 2019 Dec 1;466:13-22. (2022 SCI: 9.7) 

41. Liu S#, Du Y#, Ma H*, Liang Q, Zhu X*, Tian J*(2019). Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging. Cancer Lett. 2019 Jul 1;453:74-83. (2022 SCI: 9.7)

42. Sun W#, Du Y#, Liang X#, Yu C, Fang J, Lu W, Guo X, Tian J*, Jin Y*, Zheng J* (2019), Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer. Biomaterials. 2019 Oct;217:119264. (2022 SCI: 14) 

43. Liang Q#, Kong L#, Du Y*, Zhu X*, Tian J*(2019). Antitumorigenic and antiangiogenic efficacy of apatinib in liver cancer evaluated by multimodality molecular imaging. Exp Mol Med. 2019 Jul 8;51(7):76. doi: 10.1038/s12276-019-0274-7. (2022 SCI: 12.8) 

44. Xiong K#, Zhang H, Du Y*, Tian J*, Ding S* (2019). Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer. Exp Mol Med. 2019 Aug 26;51(8):100. (2022 SCI: 12.8) 

45. Du Y#, Jin Y#, Sun W, Fang J, Zheng J*, Tian J* (2019). Advances in molecular imaging of immune checkpoint targets in malignancies: current and future prospect. Eur Radiol. 2019 Aug;29(8):4294-4302. (2022 SCI: 5.9) 

46. Chu Tang#, Yang Du#, Qian Liang, Zhen Cheng*, Jie Tian*(2019). A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy. Journal of Materials Chemistry B. 2019 DOI: 10.1039/C9TB00383E. (2022 SCI: 7) (ranked Hot Papers)

47. Du Y#, Liang X#, Li Y#, Sun T, Xue H, Jin Z*, Tian J* (2018). Liposomal nanohybrid cerasomes targeted to PD-L1 enable dual-modality imaging and improve antitumor treatments. Cancer Lett. 2018 Feb 1;414:230-238. (2022 SCI: 9.7) 

48. Tang C#, Du Y#, Liang Q, Cheng Z*, Tian J* (2018). A Novel Estrogen Receptor α-Targeted Near-Infrared Fluorescent Probe for in Vivo Detection of Breast Tumor. Mol Pharm. 2018 Oct 1;15(10):4702-4709. (2022 SCI: 4.9)

49. Du Y#, Jiang Q#, Beziere N#, Song L, Zhang Q, Peng D, Chi C, Yang X, Guo H, Diot G, Ntziachristos V*, Ding B*, Tian J* (2016). DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy. Adv Mater. 2016 Dec;28(45):10000-10007. (2022 SCI: 29.4)

50. Zhang Q#, Jiang Q#, Li N, Dai L, Liu Q, Song L, Wang J, Li Y, Tian J, Ding B*, Du Y* (2014). DNA origami as an in vivo drug delivery vehicle for cancer therapy. ACS Nano. 2014 Jul 22;8(7):6633-43. (2022 SCI: 17.1) 

51. Jiang Q, Shi Y, Zhang Q, Li N, Zhan P, Song L, Dai L, Tian J, Du Y*, Cheng Z*, Ding B*. (2015). Self-assembled Gold DNA Nanoparticles for Cancer Theranostics. Small. 2015 Oct;11(38):5134-41. (2022 SCI: 13.3) 

52. Shang W#, Zeng C, Du Y, Hui H, Liang X, Chi C, Wang K*, Wang Z*, Tian J* (2016). Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, Adv Mater. 2017 Jan;29(3). (2022 SCI: 29.4)

53. Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y (2012). Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 2012;3:1008. doi:

1. 2023年，中国生物医学工程学会黄家驷生物医学工程奖一等奖，光学分子成像前沿技术的临床转化和推广应用（第六完成人）

2. 2023年，中华医学科学技术奖二等奖，肿瘤近红外荧光手术导航系统关键技术创新与临床推广应用（第七完成人）

3. 2022年，北京市科学技术奖自然科学奖二等奖，胰腺肿瘤影像特征机制研究与技术创新应用（第五完成人）

4. 2022年，第八届（2022年度）北京医学科技奖二等奖，胰腺肿瘤性疾病的影像学技术创新及临床应用研究（第五完成人）

5. 2023年，获全球前2%顶尖科学家榜单（World’s Top 2% Scientists 2023）

6. 2021年，获2021年度世界分子影像协会会刊（Mol Imaging Biol.）预临床研究最佳论文奖Molecular Imaging & Biology, 2020 Preclinical Paper of the Year

7. 2019年，获世界分子影像大会（World Molecular Imaging Congress，WMIC) 颁发的Industry Selected Poster Award, Montreal, Canada, September 4-7, 2019

8. 2019年，发表在Journal of Materials Chemistry B上的论文被评为2019 Journal of Materials Chemistry B Hot Papers

9. 2017年，世界分子影像大会（World Molecular Imaging Congress，WMIC) 颁发的Molecular Imaging Scholar Award, USA, September 13-16, 2017

10. 2016年，获美国肿瘤大会AACR New Horizons in Cancer Research Conference颁发的 AFLAC-supported Travel Awards，Shanghai, China, Nov 2-5, 2016

11. 2015年，获世界分子影像大会（World Molecular Imaging Congress，WMIC) 颁发的Molecular Imaging Scholar Award, Hawaii, USA, September, 2015

12. 2015年，发表在Journal of Materials Chemistry B上的论文被评为2015 Journal of Materials Chemistry B Hot Papers

13. 2015年，发表在Small期刊的论文被Wiley Material Views评为2015年Small热点文章Top 10

1. Yang Du; Jie Tian; Zhengyao Peng; Lin Yin; Qian Liang; MAGNETIC PARTICLE IMAGING (MPI) RECONSTRUCTION METHOD BASED ON RECNET MODEL, 2023-12-5, 美国, US 11,835,602 B1

2. Jie Tian; Yu An; Guanghui Li; Yang Du; Daxiang Yan; Jiaqian Li ; FLUORESCENCE MOLECULAR TOMOGRAPHY RECONSTRUCTION METHOD BASED ON PRIOR GUIDANCE OF MAGNETIC PARTICLE IMAGING, 2023-10-3, 美国, US 11,776,174 B1

3. 杜洋；田捷；温佳璇；彭正耀；孙泽雯；尹琳；梁倩；基于FDNN模型的磁粒子成像空间分辨率提升方法，中国，ZL202311183285.2

4. 杜洋；田捷；彭正耀；尹琳；安羽；梁倩；一种基于磁粒子成像的手持式乳腺肿瘤检测装置，中国，ZL202310126472.0 

5. 杜洋；田捷；彭正耀；尹琳；安羽；梁倩；基于RecNet模型的磁粒子成像重建方法，中国，ZL202210712519.7

6. 田捷；杜洋；王宇；安羽；边畅；王瀚帆；基于GCN残差连接网络的激发荧光断层成像方法，中国，ZL202110763557.0

7. 田捷；杜洋；边畅；王宇；安羽；王瀚帆；数字病理图像的细胞靶点表达预测方法、系统及装置，中国，ZL202011606836.8

8. 田捷；杜洋；王瀚帆；安羽；基于自适应参数搜索的弹性网络激发荧光断层重建系统，中国，ZL202010301564.4

9. 田捷；杜洋；孔令鑫；安羽；稀疏度自适应组正交匹配追踪的激发荧光断层重建方法，中国，ZL201910548816.0

10. 田捷；安羽；李光辉；杜洋；严达祥；李佳倩；基于磁粒子成像先验引导的荧光分子断层成像重建方法，中国，ZL202210457053.0

11. 安羽；严达祥；李光辉；杜洋；李佳倩；基于标准成像空间的高分辨率荧光分子断层成像方法，中国，ZL202210445460.X

12. 田捷；杜洋；唐初；田瑜；近红外荧光探针及其制备方法和应用，中国，ZL202210291827.7